ry

pter has introduced several approaches used for the whole genome

discovery problem. Among them, the focal point is how to

different approaches to analyse genomics patterns hidden in

data. The introduction in this chapter has covered the sequence

y alignment approaches including global and local alignment as

air-wise and multiple alignment. The emphasised point in this

s the multiple sequence comparison approaches. Therefore the

t-free and alignment-based multiple sequence alignment

es have been introduced and compared. Based on these

ions, this chapter has also shown how these approaches,

y the alignment-free approaches can be used for the whole

pattern discovery for a SARS-CoV-2 sequence research, i.e.,

he whole genome statistic can be used to interpret the difference

ndemic in different countries.